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Concurrent administration of lorazepam with probenecid could cause a more rapid onset or extended effect of lorazepam as a consequence of elevated 50 percent-lifetime and decreased overall clearance. Lorazepam dosage must be diminished by around fifty% when coadministered with probenecid.
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Danger Summary Neonates born to moms making use of benzodiazepines late in pregnancy have already been reported to practical experience indications of sedation and/or neonatal withdrawal (see WARNINGS: Neonatal Sedation and Withdrawal Syndrome and Scientific Concerns). Available facts from published observational studies of Expecting Females exposed to benzodiazepines will not report a clear Affiliation with benzodiazepines and significant beginning defects (see Details).
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